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Systems biology of cyanobacterial biofuel production

The project is part of the efforts to efficiently and economically produce so-called biofuels. Our approach is to combine photosynthesis with the synthesis of ethanol in a cyanobacterial cell. Together with our partners, we want to establish a systemic understanding of a photosynthetic prokaryote by experimental analysis of relevant metabolic pathways combined with data-based mathematical modeling. Our model organism is the unicellular cyanobacterium Synechocystis sp. PCC 6803. Well-established genetic tools together with an accumulating body of information from transcriptomic, proteomic and metabolomic data provide an excellent background for systems biology-based modeling, analytical prediction and simulation of cellular processes.
 
 
Collaboration:


Prof. T. Börner Humboldt University Berlin, Genetics

Dr.  R. Steuer Humboldt University Berlin, Theoretical Biology

Prof. W.R. Hess University of Freiburg, Genetics and Experimental Bioinformatics

CyanoBiofuels GmbH Berlin

Funding: BMBF e:bio


Publications:

Dienst D, Georg J, Abts T, Jakorew L, Kuchmina E, Börner T, Wilde A, Dühring U, Enke H, Hess WR. (2014) Transcriptomic response to prolonged ethanol production in the cyanobacterium Synechocystis sp. PCC 6803. Biotechnol Biofuels. 7:21.


Trautmann D, Voß B, Wilde A, Al-Babili S, Hess WR (20129 Microevolution in cyanobacteria: Re-sequencing a motile substrain of Synechocystis sp. PCC 6803. DNA research [Epub ahead of print] PubMed PMID: 23069868.

Kuchmina E, Wallner T, Kryazhov S, Zinchenko VV, Wilde A. (2012) An expression system for regulated protein production in Synechocystis sp. PCC 6803 and its application for construction of a conditional knockout of the ferrochelatase enzyme. J. Biotechnol. 162, 75-80.
 

 
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